Supporting Redox Biology & Oxidative Stress Research
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Changing oxidant levels associated with stress and cell signaling result in specific cellular responses.
As regulatory systems are remodeled, this creates specific and nonspecific oxidative stress biomarkers that our products can help you measure.
FEATURED ASSAY
Glutathione (GSH GSSG) Assay Kit
[NWK-GSH01]
- Excellent sensitivity as low as 5 pMol
- Can detect glutathione disulfide (GSSG) when samples are pre-treated with suitable thiol-scavenger, such as 4vinylpyridine (4VP) or NEM
Elevated levels of free radical exposure can cause modifications in biological substrates.
We offer a range of products to measure these oxidative stress biomarkers in lipid, protein, and DNA.
POPULAR ASSAY
Malondialdehyde (MDA) Assay Kit
[NWK-MDA01]
- Reduced reaction temperature minimizes the decomposition of lipid hydroperoxides.
- Optimized reaction pH facilitates hydrolysis of MDA-protein adducts for better recovery of malondialdehyde (MDA).
Inflammatory immune response results in elevated levels of oxidants.
Anti-inflammatory and pro-inflammatory agents can be important considerations when investigating the effects of oxidative stress.
FEATURED ASSAY
Myeloperoxidase Activity Assay Kit
[NWK-MPO03]
- A simple and easy colorimetric assay for the study of myeloperoxidase (MPO) activity.
If you think of your data as a type of signal or waveform it is easier to understand how and why derivative spectroscopy can be used to focus on the data of interest...
The Trouble with TBARsMentioned in connection with oxidized lipids as early as 1948, Thiobarbituric Acid Reactive Substances (TBARS) are often mentioned in discussions about malondialdehyde (MDA).
Spotlight on Protein Oxidation: DibromtyrosineDibromotyrosine is a relatively new biomarker that is indicative of oxidative stress mediated protein augmentation.
Nrf2 and the Keap1/Nrf2, Nrf2/sMaf/ARE PathwaysBridging the gap between normal redox homeostasis and oxidative stress lies a transcription factor protein known as nuclear factor erythroid 2 (Nrf2).
Alpha-1 Proteinase Inhibitor as a Redox BiomarkerA notable and often ignored feature of A1PI is that its activity can be regulated by oxidation...
More ArticlesWe are committed to providing best in class products and services related to redox and oxidative stress research. We are pleased to be of service to life science professionals investigating many of today's hottest medical, environmental and agricultural issues.
Increased levels of Oxidative Stress often results in damage to cellular components which can also be a precursor to tissue specific or systemic disease states. Our products support laboratories studying these medical conditions.
NWLSS™ products are used by investigators studying the effects of hazardous chemicals, trace metals and radiation on the environment.
Researchers are finding oxidative stress biomarkers a convenient way to assess crop and herd health. Find out how NWLSS™ products are serving today's agricultural research & industry.
What happens when environmental stress or increased metabolic activity act to create elevated conditions of oxidative stress in our cells? Researchers around the world are using NWLSS™ products to find out.
Featured Citations
Effects of betaine and ascorbic acid on tonic immobility, superoxide dismutase and glutathione peroxidase in broiler chickens during the hot-dry season
Journal of Veterinary Behavior: Clinical Applications and Research November 11, 2015
The Effects of Epidural Anesthesia on Growth of Escherichia coli at Pseudosurgical Site: The Roles of the Lipocalin-2 Pathway
Anesthesia & Analgesia July 2015; Vol. 121 - Issue 1: p 81–89
Effect of Zinc nanoparticles on oxidative stress-related genes and antioxidant enzymes activity in the brain of Oreochromis niloticus and Tilapia zillii
Saudi Journal of Biological Sciences Available online 18 November 2015(PDF)
