Peroxiredoxin II Polyclonal Antibody

NWLSS | Northwest Life Science Specialties, LLC.
nwa-prx2p091
NWA-PRX2P091 $375.00 each

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Introduction

Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with detoxification of oxidants, cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kDa in molecular size and vary in subcellular localization; Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretions and Prx V showing complicated distribution including peroxisome, mitochondria and cytosol (1) .


Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant human protein purified from E.coli
Cross Reactivity
Human, Mouse, Rat
Application(s): Western blotting (1:2000)
Storage/Stability:
Stable for 1 years at -20 °C
Packaging Size:
100 μL
Format:
Liquid

References:
(1) Wood, Z. A., et al. (2003) Trends Biochem Sci. 28(1):32-40.
(2) James W. Baty, et al.(2005) Biochem. J 3 Mar Published
(3) Rhee Sue Goo, et al (2001) IUBMB life 52:35-41
(4) Min Hee Choi, et al (2005) Nature letters 435(19):347-353

 

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